Final STREAM Stage 1 trial results published

The final results from the STREAM Stage 1 trial, which compared 9-11 months of standardized treatment using older drugs (the so-called modified "Bangladesh" regimen) to the 2011 World Health Organization (WHO)-recommended treatment, were published in the New England Journal of Medicine.

The results showed that the STREAM Stage 1 experimental regimen was non-inferior to the old WHO-recommended regimen. However, this shorter regimen contains multiple toxic and less effective medicines, including injectables that cause hearing loss, that are no longer prioritized in the 2018 WHO treatment recommendations.

Read more about the final STREAM Stage 1 trial results here:

• The Union: Stream clinical trial results prove that a nine-month treatment regimen for MDR-TB is as effective as the 20-month regimen
• Union response to release of final results from Stage 1 of the STREAM trial
• University College London: STREAM trial final results show 9-month treatment for multidrug-resistant TB is as effective as 24-month treatment
• CIDRAP: Trial data support shorter drug-resistant TB regimen
• Science Speaks: STREAM Trial: Nine-month regimen for drug-resistant tuberculosis brings “promising cure rates”
• Health-e News: Shorter cure for resistant TB