Multidrug-resistant TB prevention trials to begin

Three recent clinical trials – VQUIN, TB-CHAMP, and PHOENIx – are focusing on preventing MDR-TB among household contacts of MDR-TB patients. Two trials, VQUIN and TB-CHAMP, are studying the efficacy of levofloxacin compared to placebo treatment among household contacts. The VQUIN trial enrolled its first subject on March 14, 2016, while the TB-CHAMP trial is set to begin enrollment in Q4 of 2016. The PHOENix trial is focused on testing the efficacy of delamanid versus isoniazid treatment, and is the least far along. PHOENIx has completed a successful pilot trial and hopes to begin enrollment sometime in 2017.