Association of body mass index with timing of death during TB treatment
Abstract
Background
The association between
body mass index and mortality in patients with tuberculosis has
not been extensively studied, and the existing evidence is
inconsistent. This study aimed to investigate the impact of body
mass index on timing of death in patients with tuberculosis.
Methods
All Taiwanese adults with
tuberculosis in Taipei, Taiwan, were included in a retrospective
cohort study in 2011–2012. Multinomial logistic regression
was used to evaluate the association between body mass index and
timing of death in patients with tuberculosis.
Results
Among 1557 eligible
patients, 84.1% (1310), 8.2% (128), and 7.6% (119) underwent
successful treatment, early death, and late death, respectively.
The mean age of the patients with tuberculosis was 64.2 years
old, and 67.7% were male. After controlling for potential
confounding variables, underweight with body mass index less
than 18.5 kg/ m2 was significantly associated with elevated risk
of all-cause mortality [Adjusted odds ratio (AOR), 1.64; 95%
confidence interval (CI), 1.17–2.30]. Considering timing
of death, underweight with body mass index less than 18.5 was
significantly associated only with elevated risk of early
mortality within the first 8 weeks of treatment onset (AOR,
2.22; 95% CI, 1.45–3.40)
Conclusions
For patients with
tuberculosis infection, underweight with body mass index less
than 18.5 kg/m2 is an independent predictor for early mortality
within the first 8 weeks of treatment.
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Source:
PLOS ONE
