A dose-response relationship of smoking with TB infection: A cross-sectional study among 21008 rural residents in China
Abstract
Objectives
China has high burden on
both of tuberculosis (TB) and tobacco use. This study aims to
explore the potential link between smoking and TB infection
using baseline survey data of a large-scale population-based
prospective study in rural China
Methods
Between July 1 and Sept 30,
2013, based on the baseline survey of a population-based,
prospective study in rural China, the relationship between
smoking and TB infection, assessed by interferon-gamma release
assays (IGRA), was investigated among the total study population
and only among those smokers, respectively.
Results
A total of 21,008 eligible
rural registered residents (≥ 5 years old) from 4 rural sites
were included in the analysis. Ever-smokers were more likely to
be QuantiFERON-TB Gold In-Tube (QFT) positive than never smokers
with an adjusted odds ratio (OR) of 1.34 (95% confidence
interval (CI): 1.21–1.49). Among ever smokers, a
significant linear dose–response relation was observed
between duration of smoking (by years) and QFT positivity (p
< 0.001). Stratified analysis suggested that such an
association was not influenced by gender and age. Evidence for
interaction of smoking status with age was found.
Conclusions
Our results provide
further evidence to support smoking might increase host
susceptibility to TB infection. Populations under high risk of
infection, such as elderly smokers, should be prior to TB
infection controlling under a premise of community level
intervention.
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Source:
PLOS ONE
