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Jef Akst

Investigation questions transparency for failed TB vaccine

The BMJ inquiry finds that researchers presented only select results from animal experiments when applying for funding and approval for human trials.

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TB over time

In 1997, when the field of paleomicrobiology was just emerging, University College London microbiologists Helen Donoghue and Mark Spigelman attended a conference in Hungary focused on the evolution of Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). A few years earlier, Spigelman and PhD student Eshetu Lemma had published the first paper on ancient M. tuberculosis DNA, examining centuries-old samples using PCR (Int J Osteoarchaeol, 3:137-43, 1993). At the conference, Spigelman and Donoghue presented work they’d done to recover M. tuberculosis DNA from much-more-recent human skeletal remains, collected as part of a forensic case dating to the mid-20th century.

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