Computational method for screening drug compounds can help predict which ones will work best against tuberculosis or other diseases.

Shortening carbohydrates in the bacterial cell wall makes them more vulnerable to certain drugs.

Tuberculosis is one of the world's deadliest infectious diseases: One-third of the world's population is infected with TB, and more than 1 million people die from the disease every year.

Antibiotic resistance is a growing problem, especially among a type of bacteria that are classified as “Gram-negative.” These bacteria have two cell membranes, making it more difficult for drugs to penetrate and kill the cells.

Researchers at MIT and Brigham and Women’s Hospital have developed a new drug capsule that remains in the stomach for up to two weeks after being swallowed, gradually releasing its drug payload. This type of drug delivery could replace inconvenient regimens that require repeated doses, which would help to overcome one of the major obstacles to treating and potentially eliminating diseases such as malaria.