ART and tuberculosis: the final nail in nevirapine's coffin?

Concomitant administration of antituberculosis treatment and ART is associated with drug interactions, mediated largely by the inducing effect of rifampicin, and shared drug toxicity. Few controlled studies have compared different ART regimens in patients with tuberculosis, and thus the report by Maryline Bonnet and colleagues in The Lancet Infectious Diseases of the CARINEMO study,a randomised comparison of nevirapine-based ART with efavirenz-based ART in participants with tuberculosis, is welcome.