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Keith Alcorn

Countries and donors should aim for new $90-$90-$90 target on HIV, hepatitis, TB drug prices, study shows

HIV, hepatitis B and C and TB can each be treated for less than $90 a year where generic drugs can be made available, Dzintars Gotham of Imperial College, London, reported at the 9th International AIDS Society Conference on HIV Science in Paris.

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Nix-TB trial: Good results for three-drug regimen against XDR-TB (BPaL)

A regimen of three oral drugs given for six months was enough to clear extensively drug-resistant tuberculosis (XDR-TB) in 29 of the first 31 people to have completed the treatment course, Dr Francesca Conradie of Sizwe Tropical Disease Hospital, Johannesburg, told the 2017 Conference on Retroviruses and Opportunistic Infections (CROI). If the results are replicated in a larger population, the findings could revolutionise the prospects for treating not just XDR-TB, but also the more severe cases of MDR-TB (multidrug-resistant tuberculosis).

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Isoniazid preventive treatment reduces the risk of death by 37% in people living with HIV

A six-month course of isoniazid preventive treatment (IPT) at the beginning of the Temprano trial in Ivory Coast reduced the risk of death by 37% over a mean follow-up period of 4.5 years, Anani Badje reported at the 2017 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle on Wednesday.

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New $90-$90-$90 target needed for global viral hepatitis, HIV and TB treatment

The costs of making drugs to treat viral hepatitis, HIV and TB are now so low that each disease could be treated for less than $90, Dr Andrew Hill of St Stephen’s AIDS Trust told the opening plenary of the International Congress on Drug Therapy in HIV Infection in Glasgow on Sunday (October 23).

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Package of prophylaxis against infections reduces the risk of death for people starting HIV treatment very late

A package of enhanced prophylaxis against infections significantly reduced the risk of death in adults and children with advanced HIV disease after starting antiretroviral treatment in a randomised study, Professor James Hakim of the University of Zimbabwe told the 21st International AIDS Conference in Durban, South Africa, last month.

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Large-scale household TB screening shows feasibility in PopART trial

Offering TB screening as part of a home-based HIV testing intervention has the potential to identify numerous TB cases that would otherwise have gone undiagnosed, a report from a large community-based study in Zambia shows. The findings, from the PopART study, were reported by Comfort Phiri of Zambart at the 2016 Conference on Retroviruses and Opportunistic Infections in Boston on Thursday (February 25).

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Death during MDR-TB treatment more likely in people with HIV and underweight or most drug-resistant patients

People living with HIV, those who are underweight and those with more extensive drug resistance are more likely to die during treatment for multidrug-resistant tuberculosis (MDR-TB), a nine-country study has found. The findings were presented at the 46th Union World Conference on Lung Health in Cape Town last week.

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Newest MDR-TB drug prices could fall by up to 95% through generic production

The cost of newer drugs for the treatment of multidrug-resistant tuberculosis could be cut by up to 95% if generic production of patented products could be achieved in the same way as for antiretroviral drugs.

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TB death rate four times higher in Eastern Europe due to lack of HIV treatment after TB diagnosis

People living with HIV in Eastern Europe who develop tuberculosis (TB) are four times more likely to die within a year when compared to similar patients in Western and Southern Europe or Latin America, a large international study presented on Thursday at the 15th European AIDS Conference in Barcelona has shown.

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Three-month isoniazid/pyrazinamide regimen prevents TB as well as 6-month isoniazid in people living with HIV

A daily three-month regimen of isoniazid and pyrazinamide is just as effective at preventing the development of active tuberculosis (TB) as a six-month course of isoniazid in people living with HIV, a Russian study has shown. The findings were presented by Dr Zinaida Zagdyn at the 15th European AIDS Conference in Barcelona on Thursday.

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