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Mark Mascolini

Sputum smears mistake other bacteria for TB in HIV+ Nigerians

Sputum smear microscopy to identify acid-fast bacilli incorrectly identified other bacteria as Mycobacterium tuberculosis in a study of 415 HIV-positive people in Nigeria.

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Doubled risk of TB diagnosis in Nigerians with poor ART response

Nigerian adults with a poor CD4 or virologic response to antiretroviral therapy (ART) had a doubled or tripled risk of a new TB diagnosis, according to results of a 5000-person study.

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Higher AIDS but not death rate in migrants to Europe, US, and Canada

During their first year of antiretroviral therapy (ART), migrants in Europe, the United States, and Canada had a 20% higher rate of new AIDS-defining events than nonmigrants, according to results of a 48,854-person analysis. But migrants did not have a higher death rate in the first year of ART.

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ART cuts risk of new TB in 9-month study of 5040 Tanzanian children

Antiretroviral therapy (ART) cut the risk of newly diagnosed tuberculosis by 70% in a longitudinal study of 5040 HIV-positive children in Tanzania. Older age and more advanced HIV disease raised the risk of TB.

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Low albumin predicts death, TB, weight loss in Tanzanians starting ART

Low serum albumin independently predicted death, pulmonary tuberculosis, severe anemia, and weight loss in a 21-month study of 2145 Tanzanian adults starting antiretroviral therapy (ART).

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Antimalarial levels sharply lower with rifampin in HIV+ in Uganda

Concentrations of the antimalaria drugs artemether and lumefantrine were sharply lower during rifampin-based anti-TB therapy in Ugandan adults with HIV. The researchers recommend avoiding simultaneous use of artemether-lumefantrine and rifampin.

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Nevirapine not equivalent to EFV in Mozambicans with HIV and TB

A nevirapine-based antiretroviral regimen failed to attain noninferiority with an efavirenz (EFV) regimen in a randomized trial of Mozambican adults being treated for tuberculosis and starting their first antiretroviral combination.

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Prior TB triples risk of later active TB in HIV+ people of Tanzania

Having tuberculosis in the past approximately tripled the risk of later active TB in a large study of HIV-positive Tanzanians with or without prior TB.

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WHO TB screen has low sensitivity in patients on ART in South Africa

The World Health Organization (WHO) symptom screening algorithm for tuberculosis had low sensitivity in identifying TB among South African HIV patients, especially those taking antiretroviral therapy (ART). The findings have implications for starting isoniazid preventive therapy (IPT).

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Higher risk of TB recurrence with HIV reduced by ART in Malawi

Compared with HIV-negative people, those with HIV had a higher risk of recurrent tuberculosis in a prospective study in Malawi. Among people with HIV, taking antiretroviral therapy (ART) lowered the risk of recurrent TB.

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