-- CHMP recommends Conditional Marketing Authorisation be converted into standard Marketing Authorisation

-- Recommendation supported by results from the Phase 3 STREAM Stage 2 study, which show bedaquiline-containing regimens offer significant improvement compared to other available therapies

Experts are working on novel immune-enhancing therapies called host-directed therapies to use the body's own immune system to target tuberculosis, with hopes that they could tackle even the drug-resistant forms of the disease. In a presentation at this year's ESCMID Global Congress (formerly ECCMID) in Barcelona (27–30 April), Associate Professor Susanna Brighenti, Center for Infectious Medicine (CIM), ANA Futura at the Karolinska Institutet, Stockholm, Sweden, presents work being done in this area by a collaboration of scientists.

The International Journal of Tuberculosis and Lung Disease (IJTLD) is the official publication of the International Union Against Tuberculosis and Lung Disease (The Union).

Transparency on clinical trial costs must become the norm to improve access to medical products worldwide.

Mycobacterium tuberculosis, the bacteria that causes tuberculosis (TB), is distinct from most germs in its capacity to silently infect individuals for months and even years before waking up and causing active disease that can lead to severe illness and death. The immune system plays an important role in controlling the germ and keeping it dormant.

The occurrence of adrenal insufficiency was relatively common in patients infected with HIV or TB and predicted by nonspecific clinical features, including weight loss, myalgia, arthralgia, and abdominal pain.

Safeguarding children against TB takes center stage with introduction of child-friendly formulation of rifapentine for short-course TB preventive treatment.

A study published this week in The Lancet Infectious Diseases highlights the substantial impact of infectious diseases on global health.

Aside from addressing stigma and improving detection, perhaps most important is recognising that TB is both a social and an economic disease.

New research led by Qingyun Liu, PhD, assistant professor in the UNC Department of Genetics, has uncovered a genetic feature known as “transcriptional plasticity,” which plays a pivotal role in governing the transcriptional response of Mycobacteria to stressful conditions.