Wellcome and the Bill & Melinda Gates Foundation announce US$550 million funding to advance a TB vaccine candidate, M72/AS01E, through a Phase III clinical trial that could be the first in 100 years if proven effective.

The information notes complement the updated WHO guidelines and operational handbook on the management of TB in children and adolescents released in 2022.

27 June 2023 | Geneva: WHO's Global Tuberculosis Programme has initiated a process to review the evidence on TB and nutrition to update the previous WHO guidelines: Nutritional care and support for patients with tuberculosis.

In a recent study published in the Journal of Infection, researchers performed a systematic literature review of global treatment outcomes of extensively drug-resistant Tuberculosis.

The International Journal of Tuberculosis and Lung Disease (IJTLD) is the official publication of the International Union Against Tuberculosis and Lung Disease (The Union).

The UK Health Security Agency released a report presenting people with TB disease notified to the enhanced surveillance scheme in England and aiming to describe the epidemiology of TB in England up to the end of 2021. It is the sixth in a series of 7 reports that will describe different aspects of TB incidence, treatment and prevention in England.

According to the World Health Organization, each year there are approximately three million undiagnosed cases of tuberculosis (TB) globally, which are characterized as the "missing millions." In a cutting-edge study, scientists have tested a diagnostic device using dielectrophoresis that holds promise for improving TB detection and treatment of patients in high-endemic, under-resourced areas. Bringing diagnostics to the patients who need it most will help meet global targets to reduce the burden of TB. The research results appear in The Journal of Molecular Diagnostics.

TOPLINE:

Down-regulation of plasma exosome-derived apolipoproteins APOA1, APOB, and APOC1 indicates DR-TB status and lipid metabolism regulation in pathogenesis. 

The following is a summary of “Ending tuberculosis in a post-COVID-19 world: a person-centred, equity-oriented approach,” published in the February 2023 issue of Infectious Diseases by Ryckman, et al.

In March this year, the director-general of the Northern Cape government, Justice Bekebeke during a parliamentary oversight visit acknowledged that about 80% of the health facilities in the province did not meet their TB performance targets of finding TB cases and ensuring successful (completed) treatment.