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Brief news reports on Tuberculosis

Methods combine to decode the biology of tuberculosis

Scientists are fusing sequencing, chemistry and imaging techniques to probe interactions between pathogens and their host cells.

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This vaccine could save tens of thousands of South African lives each year, but we’ll only see it in 2030

In 2019, the World Health Organisation (WHO) hailed the results of a candidate tuberculosis (TB) vaccine as a major scientific breakthrough. But years later we are not much closer to seeing the vaccine. Why do TB vaccines take so long to develop compared to Covid vaccines?

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IJTLD May 2022 issue now online

The International Journal of Tuberculosis and Lung Disease (IJTLD) is the official publication of the International Union Against Tuberculosis and Lung Disease (The Union).

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Usefulness of monitoring IgG against antigen 85B for prediction of TB development from latency: from an elephant TB analysis

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb); the leading cause of human death due to a single pathogen before the emergence of SARS-CoV-2. In elephants, the infections and deaths with TB have been reported worldwide, and elephant-to-human transmission has also been reported. Therefore, elephant TB is a concern for both conservation of this endangered animal and public health.

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Researchers identify rare genetic markers of drug-resistant TB

Search for rare mutations in bacterial genome could lead to better diagnostics and treatments – reducing morbidity caused by the deadly disease.

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Outcomes, safety of weight-based bedaquiline in children with multidrug-resistant TB

Weight-based dosing of bedaquiline for multidrug/rifampicin-resistant (MDR/RR) tuberculosis (TB) infection was safe and effective among children with and without HIV coinfection, according to findings published in Clinical Infectious Diseases.

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Chronic bacterial infections associated with an increased risk for ischemic stroke

A significant association was observed between chronic infections caused by Chlamydia pneumoniae, Helicobacter pylori, and Mycobacterium tuberculosis bacteria and an increased risk for ischemic stroke, according to findings published in New Microbes and New Infections.

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Evaluation of the potential of new and repurposed TB vaccines

Scientists reported that tuberculosis (TB) is one the foremost causes of global mortality, especially in adults. In 2019, around 10 million TB cases were reported, many of which were identified to be resistant to multiple drugs.

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South Africa: How do we make an HIV and TB plan that has greater impact?

There is good reason to be sceptical about the link between healthcare policy and implementation in South Africa. Policies such as those on mental health and palliative care, for example, may be good on paper but have generally gone unimplemented. The Competition Commission’s Health Market Inquiry is arguably one of the most impressive and thorough investigations into a set of healthcare issues in recent years but most of the HMI report’s recommendations are gathering dust.

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India planned to eliminate TB by 2025, but it’s estimated half a million Indians are still dying from it every year

In India in 2021, an estimated 504,000 people died from tuberculosis, or TB. That’s almost one per minute. More than a quarter of the estimated TB cases worldwide are in India.

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