Items tagged with Drug-resistant TB
Analysis: Not all good news in new WHO MDR-TB recommendations (post)
In a move that could help save the hearing of thousands of people with TB, the World Health Organisation (WHO) is advising wider use of newer and repurposed drugs, bedaquiline and linezolid in place of injections that cause deafness. Rather perplexingly, the WHO is however also maintaining its recommendation for a shorter and cheaper, but much less impressive treatment regimen and advised that the new South African regimen should only be used under conditions of operational research.
Inching closer to a soft spot in isoniazid-resistant TB (post)
Antibiotic-resistant tuberculosis is a public health threat. TB and other bacteria become resistant to antibiotics by evolving genetic changes over time, which they can do quite quickly because bacterial lifecycles are short. In fact, it takes only a single genetic mutation to grant TB resistance to isoniazid, one of the first-line antibiotics.
New method may allow country-level real-time surveillance of drug-resistant TB (post)
Global tuberculosis control and elimination will require detailed real-time information on the location of individuals with the disease, the presence of drug resistance, and the patterns of transmission. The surveys currently used are only conducted periodically and are not sufficient to effectively control tuberculosis, which causes more than 4,500 deaths daily. In August in PLOS Medicine, Karen Jacobson, from the Boston University School of Medicine and Boston Medical Center, and colleagues, describe a new technique for linking samples submitted for tuberculosis testing to the individuals who provided the samples and the location from where they were submitted, in a way that can provide the continuous national surveillance necessary for eradicating tuberculosis and drug-resistant tuberculosis.
Study shows children with multidrug-resistant TB can be treated (post)
The results of a large, international systematic review published in the journal PLOS Medicine show that tuberculosis treatment is successful in children with multidrug-resistant tuberculosis (MDR-TB). The study was used to inform the World Health Organization guidelines on treatment of MDR-TB in children.
Substituting bedaquiline for second-line injectables improves MDR-TB treatment (post)
Findings from a recent study support substituting bedaquiline for second-line injectables in treatment for multidrug-resistant tuberculosis, with researchers reporting improved outcomes at 12 months compared with patients who remained on second-line injectables.
Documentary: Two Countries, Two Choices: India, South Africa and the struggle against MDR-TB (post)
A new documentary film by AIDS-Free World: The drugs bedaquiline and delamanid can mean the difference between life and death for people suffering from the worst and most noxious strain of TB in the world, multidrug-resistant TB (MDR-TB). The government of India has restricted access to the drugs for its 140,000 MDR-TB sufferers. South Africa has made a different choice for 20,000 MDR-TB patients. The consequences are profound.
Delamanid delay comes home (post)
A note from the field in this week’s Morbidity and Mortality Weekly Report describes the case of a dangerously ill man in the United States. Weak, coughing, and losing weight, with pain in his chest, he was tested for tuberculosis, which it turned out he had, and put on the first-line of treatment for the disease.
Complete makeover in fight of multidrug-resistant TB (post)
Montreal, Sep 6, 2018 – Several new medicines have been found to be more effective than traditional ones used to treat multidrug-resistant tuberculosis (MDR-TB), according to a new international collaborative study led by Dr. Dick Menzies, senior scientist at the Research Institute of the McGill University Health Centre (RI-MUHC) in Montreal. These findings precipitated a complete overhaul of worldwide TB treatment guidelines, with the results of this work published today in the British medical journal The Lancet.
European Union Standards for Tuberculosis Care - 2017 update (post)
The European Centre for Disease Prevention and Control (ECDC) and the European Respiratory Society (ERS) have developed 21 patient-centred standards to guide clinicians and public health workers in their work to ensure optimal diagnosis, treatment and prevention of tuberculosis (TB) in Europe. In 2017, the European Union Standards for Tuberculosis Care (ESTC) were updated to incorporate the most recent technological developments and international recommendations for TB diagnosis, treatment and prevention.
Better and safer treatment for multidrug-resistant TB (post)
Paul Farmer in a comment, published in The Lancet, reflects on the "new era" of better and safer treatment for multidrug-resistant TB.
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