Items tagged with Extrapulmonary TB
M. tuberculosis prosthetic joint infection rare but possible in some patients (post)
Although prosthetic joint infections caused by Mycobacterium tuberculosis are rare, they may occur in immunocompromised patients or in people from regions where tuberculosis is endemic, researchers reported in a recent study.
Detecting TB outside the lungs (post)
According to the WHO, a total of 1.5 million people died from tuberculosis (TB) in 2020. It is second only to COVID-19 as a leading cause of death as a result of an infectious disease, with over 95% of cases and deaths occurring in developing countries.
Higher dose antibiotic shown safe in TB patients likely more effective in treating deadliest form of TB (post)
A Johns Hopkins Children’s Center-led study in animals suggests that high doses of a widely used antibiotic called rifampin may safely treat and reduce the duration of treatment for the deadliest form of tuberculosis that affects the brain, potentially improving survival rates for patients and decreasing the likelihood of lasting adverse effects of the disease. Additional studies in a small number of people also shed light on how rifampin moves through the body, including into the brain, and how rifampin levels could change during treatments, showing how the research could potentially translate to humans.
Study shows FDA-approved TB regimen may not work against the deadliest form of TB due to multidrug-resistant strains (post)
Findings from a Johns Hopkins Children's Center study in animal models show that a U.S. Food and Drug Administration (FDA)-approved antibiotic regimen for multidrug-resistant (MDR) tuberculosis (TB) may not work for TB meningitis. Studies in a small number of people also provide evidence that a new combination of drugs is needed to develop effective treatments for TB meningitis due to MDR strains.
Primary adrenal insufficiency contributes to mortality in adrenal TB (post)
Primary adrenal insufficiency (PAI) is a common manifestation in patients with adrenal tuberculosis (ATB) and contributes to mortality, according to a study published in the Journal of the Endocrine Society.
Steroid fails to boost survival in advanced HIV patients with TB meningitis (post)
Adding dexamethasone to treatment for tuberculous (TB) meningitis among heavily immunosuppressed HIV-positive patients in a low-resource setting did not significantly improve survival or confer any other measured benefits, a randomized controlled trial showed.
NIH clinical trial of TB meningitis drug regimen begins (post)
A trial of a new drug regimen to treat tuberculous meningitis (TBM) has started enrolling adults and adolescents in several countries where tuberculosis (TB) is prevalent. The Improved Management with Antimicrobial Agents Isoniazid Rifampicin Linezolid for TBM (IMAGINE-TBM) trial will compare a six-month regimen of four drugs with the nine-month, standard-of-care regimen for TBM. The study aims to generate evidence that could improve treatment for people with TBM. IMAGINE-TBM is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and implemented through the NIAID-funded Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACTG).
TB may increase the risk for systemic vasculitides (post)
The risk for systemic vasculitides (SV) is increased among patients with tuberculosis (TB), especially among those with extrapulmonary disease, according to study findings published in Rheumatology.
Researchers report potential new treatment regimens for multidrug-resistant TB meningitis (post)
Investigators used PET scans to develop what they believe will be better use of existing drugs to target TB infections in the brain and spine.
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