Items tagged with Scientific research
Innate immune defenses triggered by unsuspected mechanism (post)
To the amazement of researchers in immunology and genetics, a previously unsuspected mechanism is activated in the presence of pathogens after only a few hours. "In the hours following an attack by bacteria, we observed the activation of thousand of genes in the cells of the innate immune system (the one we are born with) and the triggering of its immune defences," said Luis Barreiro, a researcher at the Sainte-Justine University Hospital Center (CHU Saint-Justine) and professor at the University of Montreal. "We were surprised that the bacterial infection caused thousands of changes in DNA methylation, while this epigenetic imprint was thought to be stable and non-reactive to environmental perturbations," he added.
Scientists take steps to make weak TB drugs strong again (post)
January 19, 2016 - Biophysicists have discovered why the bacteria that cause tuberculosis (TB) are naturally somewhat resistant to antibiotics known as fluoroquinolones. Their findings, based on mapping the detailed three-dimensional structure of the drugs interacting with an essential enzyme in the TB germ, also reveal why some TB drugs are more potent than others and suggest how drug developers can make fluoroquinolones more efficacious against mutations that make the lung disease drug resistant.
Tuberculosis: discovery of a critical stage in the evolution of the bacillus towards pathogenicity (post)
It is the disappearance of a glycolipid from the bacterial cell envelope during evolution that may have considerably increased the virulence of tuberculosis bacilli in humans. Scientists from the CNRS, the Institut Pasteur and the Université Toulouse III – Paul Sabatier1 have hown that this disappearance modified the surface properties of Mycobacterium tuberculosis, favoring its aggregation in "cords" and increasing its pathogenicity. These findings, which enable a better understanding of the mechanisms linked to the evolution and emergence of tuberculosis bacilli, constitute a major advance in our knowledge on this disease. They are published in Nature Microbiology on 27 January 2016.
Research helps intensify battle against TB (post)
Preventing the tuberculosis (TB) bacterium from producing its own vitamin could be key in the battle against the disease, according to a study done at the Faculty of Medicine and Health Sciences (FMHS) at Stellenbosch University (SU).
New understanding of TB could lead to personalised treatments (post)
Tuberculosis (TB) used to kill one in seven people around the world before the advent of antibiotics. However the increasing prevalence of multi-drug resistant TB means that doctors are running out of options in trying to combat this bacterium.
New theorem helps reveal tuberculosis’ secret (post)
February 22, 2016 - A new methodology developed by researchers at Rice and Rutgers universities could help scientists understand how and why a biochemical network doesn’t always perform as expected. To test the approach, they analyzed the stress response of bacteria that cause tuberculosis and predicted novel interactions.
Collaboration to develop new treatments for tuberculosis (post)
World-leading medicinal chemistry and biology at the Universities of Dundee (Scotland) and Cape Town (South Africa) have been allied to the industrial expertise of the Pharmaceuticals Division of Bayer (Germany), one of the world’s leading pharma companies, in an effort to develop critically needed new treatments for tuberculosis (TB).
HIV patients in Africa with a specific genetic variant have much lower rate of TB (post)
In the first known discovery of its kind, a Case Western Reserve University School of Medicine-led team has found that HIV patients in Africa with a certain genetic variant have a 63-percent lower chance of developing tuberculosis than HIV patients without the genetic variant.
Statins cut tuberculosis treatment time in mice (post)
In a study using mice, the Johns Hopkins University School of Medicine infectious disease experts have added to evidence that statin drugs — known primarily for their cholesterol-lowering effects — can significantly reduce the time it takes to clear tuberculosis infection.
Tackling tuberculosis using crowd-sourced super computer (post)
Computer crowdsourced research project launched on World tuberculosis (TB) Day will help scientists better understand and overcome this deadly disease. Volunteer your spare computer resources today.
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