Items tagged with Scientific research
‘Survival gene’ stops strains of TB mutating into deadly ‘superbugs’ (post)
Scientists have discovered a key ‘survival gene’ that prevents strains of tuberculosis (TB) from mutating into drug-resistant ‘superbugs’.
Parasite protein could help inform new anti-TB strategies (post)
Proteins produced by the parasite that causes toxoplasmosis may be involved in immune system processes that can help fight mycobacteria, according to a new study. The findings, published in PLOS Pathogens, suggest that these proteins could potentially play a role in new treatment strategies for tuberculosis.
CRISPR variant produces TB-resistant cows (post)
With over 10 million active cases in 2015 and close to 2 million deaths, tuberculosis (TB) remains a leading cause of death worldwide. Moreover, the rampant spread of drug-resistant TB has rendered many common therapies and vaccines useless. Yet now, a team of researchers from the College of Veterinary Medicine at Northwest A&F University in Shaanxi, China, has successfully utilized an innovative form of the genome-editing technique CRISPR to insert a new gene into the cow genome, rendering the animals much more resistant to tuberculosis.
Atomic-scale view of bacterial proteins offers path to new TB drugs (post)
With the first detailed analysis of a cellular component from a close relative of the pathogen that causes tuberculosis, Rockefeller scientists are suggesting strategies for new drugs to curb this growing health problem. Each year, nearly half a million people around the world are infected with mutant TB strains capable of evading existing antibiotics.
Researchers use tiny 3D spheres to combat TB (post)
Researchers at the University of Southampton have developed a new 3D system to study human infection in the laboratory.
A “release and kill” strategy may aid treatment of tuberculosis (post)
Mycobacterium tuberculosis has been called “the perfect pathogen.” These bacteria hijack human macrophages, persist inside the cells to evade immune destruction, and then prevent the macrophage from undergoing programmed cell death. This provides a niche where they grow in a protected environment that is hard to reach with antibiotics.
New TB drug candidates developed from soil bacteria (post)
A new treatment for tuberculosis (TB) is set to be developed using compounds derived from bacteria that live in soil -- according an international collaboration of researchers, including the University of Warwick.
Biological version of malware reverses antibiotic resistance in TB (post)
As the mycobacterium that causes tuberculosis has frighteningly become resistant to one drug after another, scientists for years have searched for new compounds that will stop the pathogen before it kills. Now, in a novel twist, researchers have found a way to recruit help from none other than Mycobacterium tuberculosis itself to make the deadly pathogen susceptible to an existing tuberculosis (TB) drug that it has learned to dodge.
The multinational network of TB Portals advances TB research (post)
In the current environment of limited tuberculosis research funding, TB research can benefit significantly from data-centric collaborations, as researchers can learn from the work and experiences of others, propelling their own research forward, and they facilitate larger meta-analyses of existing data.
RCDD reports on a new way of screening potential treatments for TB (post)
In a paper published in Scientific Reports scientists from LSTM’s Research Centre for Drugs and Diagnostics (RCDD) have described a new way of screening potential treatments for Tuberculosis (TB), which may assist in the identification and prioritisation of new therapies which could potentially reduce the duration of current TB treatment.
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