Items tagged with Scientific research

Novel property of a new TB drug (post)

University of Otago researchers have discovered a novel property of a new anti-tuberculosis drug which may help develop more drugs to treat the top infectious disease killer in the world.

Study finds smoking impairs the bioenergetic immune response to Mtb infection (post)

Smoking and tuberculosis (TB) have always had a strong epidemiological association. Smokers’ alveolar macrophages (AM) have demonstrated significant immune defects following infection; however, recently, macrophage glycolytic reprogramming has become the early host immune response to mycobacterium tuberculosis (Mtb) infection, according to researchers.

Enzyme discovery could help in fight against TB (post)

An enzyme structure discovery made by scientists at the University of Warwick could help to eradicate tuberculosis (TB).

How Mycobacterium tuberculosis escapes death in macrophages (post)

The bacteria that cause the devastating disease tuberculosis have the ability to escape destruction and grow after they are engulfed by lung macrophages, the immune cells that are supposed to destroy pathogens. Now researchers at the University of Alabama at Birmingham have described key biochemical steps between the bacteria Mycobacterium tuberculosis and the macrophage responsible for that ability.

Latest TB research publications (post)

Alcohol increases TB-related deaths in young mice (post)

Alcohol increases the mortality of young but not old mice infected with the tuberculosis-causing bacterium Mycobacterium tuberculosis (Mtb), and this effect is mediated by the production of a protein called interferon-alpha (IFN-α). The study, led by Deepak Tripathi of the University of Texas Health Science Center, will be published August 2 in the open-access journal PLOS Pathogens.

Research shows how hungry bacteria sense nutrients in their environment (post)

University of Leicester research sheds light on how bacteria regulates metabolism which could help to combat infectious diseases including tuberculosis.

New approach to fight TB, a leading cause of death worldwide (post)

SAN FRANCISCO, CA—Tuberculosis is one of the top 10 causes of death worldwide. Nearly 2 million people die every year from this infectious disease, and an estimated 2 billion people are chronically infected. The only vaccine, developed almost 100 years ago, offers limited protection and patients are becoming increasingly resistant to available drugs.

How damaging immune cells develop during TB (post)

Insights into how harmful white blood cells form during tuberculosis infection point to novel targets for pharmacological interventions, according to a study published in the open-access journal PLOS Pathogens by Valentina Guerrini and Maria Laura Gennaro of Rutgers New Jersey Medical School, and colleagues.

Latest TB research publications (post)