Items tagged with Scientific research
Indian scientists figure out how antidepressants hit TB bacteria (post)
The mechanism by which two small molecules work against the bacterium mycobacterium tuberculosis (Mtb) has been deciphered at a laboratory by scientists at the Indian Institute of Science. These molecules, imipramine and norclomipramine, are not routinely used antibacterials — they are in fact antidepressants.
Johnson & Johnson will make clinical data available to outside researchers (post)
The health care giant Johnson & Johnson has agreed to make detailed clinical trial data on its medical devices and diagnostic tests available to outside researchers through a collaboration with Yale University, making it the first large device manufacturer to systematically make such data public.
Antiangiogenesis drugs could make major improvement in tuberculosis treatment (post)
Use of the same antiangiogenesis drugs that have improved treatment of some cancers could also help surmount persistent difficulties in treating tuberculosis (TB). In their PNAS Early Edition report, investigators from Massachusetts General Hospital (MGH) and the National Institute of Allergy and Infectious Disease (NIAID) show that blood vessels supplying pulmonary granulomas – dense masses of immune cells that surround pockets of the TB bacteria in the lungs of infected patients – have the same sort of structural and functional abnormalities seen in solid tumors and that treatment with the antiangiogenesis drug bevacizumab (Avastin) significantly improved delivery of a small-molecule drug surrogate within granulomas in an animal model.
Chinese scientists construct first Mycobacterium tuberculosis proteome microarray (post)
Tuberculosis (TB), an ancient, yet re-emerging infectious disease, is responsible for more deaths than almost all other infectious diseases, and the vaccine, drugs and diagnostic tests currently in use are limiting the effectiveness of global efforts to prevent and control TB. The BCG vaccine, the only licensed TB vaccine, has now been in use for almost one hundred years; however, it provides only limited protection. Drugs currently used to treat TB have been in use clinically for almost half a century and bacterial drug resistance is a growing problem. In addition, current methods for detecting TB are not very effective, and the detection rate is low. Suitable biomarkers which can be used in rapid screening methods for TB are lacking.
Anticipating resistance (post)
Using computational algorithms and experimental evolution, researchers are predicting antimicrobial-resistance patterns to improve drug design.
NIH expands key tuberculosis research program (post)
The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is expanding its Tuberculosis Research Units (TBRU) program in an effort to drive innovation in tuberculosis (TB) research. NIAID is awarding up to $15.2 million in fiscal year 2015 and as much as $105.3 million over seven years to fund four institutions that will act as a collaborative TBRU network.
UGA researchers discover potential treatment for drug-resistant tuberculosis (post)
Athens, Ga. - Researchers at the University of Georgia have developed a new small molecule drug that may serve as a treatment against multidrug-resistant tuberculosis, a form of the disease that cannot be cured with conventional therapies. They describe their findings in a paper published recently in Bioorganic and Medicinal Chemistry Letters.
Immunological Reviews: Special issue on tuberculosis (post)
The issue consists of 25 articles from the world's leading experts on tuberculosis. The articles inform about the basic biology of the Mycobacterium organism, factors that regulate its virulence, how the host responds to the pathogenic challenge, and collectively how this new knowledge gives promise for potential novel interventions. Given the increasing prevalence of multidrug-resistance tuberculosis, the control of disease will be possible only through a thorough understanding of this organism and its relationship to the host immune response.
New research could identify those most susceptible to tuberculosis (post)
A team of scientists led by the University of Aberdeen has identified a key receptor involved in the control of tuberculosis (TB) which could help to identify those most likely to get the infection.
Johns Hopkins researchers identify key to tuberculosis resistance (post)
The cascade of events leading to bacterial infection and the immune response is mostly understood. However, the molecular mechanisms underlying the immune response to the bacteria that causes tuberculosis have remained a mystery — until now. Researchers at the Johns Hopkins University School of Medicine have now uncovered how a bacterial molecule controls the body’s response to TB infection and suggest that adjusting the level of this of this molecule may be a new way to treat the disease. The report appears this week as an advance online publication of Nature Medicine.
Page 7 of 74 · Total posts: 0
←First 6 7 8 Last→