Items tagged with Treatment
CROI 2015: High-dose rifampin shortens time to tuberculosis clearance (post)
A combination regimen containing high-dose rifampin (also known as rifampicin) was associated with faster tuberculosis bacteria culture conversion in people with drug-sensitive TB, but moxifloxacin and the experimental drug SQ109 showed no benefit compared to standard therapy, according to results from a study presented at the recent 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle.
Hear to help: Enabling early detection of hearing loss resulting from anti-tuberculosis treatment to improve the lives of our patients (post)
25 March 2015 - South Africa - South Africa has one of the highest levels of multidrug-resistant tuberculosis (MDR-TB) in the world, affecting 15,400 people in 2012 alone. Current standard of care for the disease involves the use of toxic medicines, which, among other side effects, can also cause hearing loss in about 30% of patients.
Not to blame the victim. Non-adherence to tuberculosis treatment: A multidimensional problem. What can we do? (post)
09 April 2015 - Poor adherence, besides causing medical and psychosocial complications, undermines the quality of life of patients, impacting more strongly in families with fewer resources. The interdependent relationship between economic poverty and disease is given by the synergistic relationship between health and socioeconomic status.
Khayelitsha clinic leads the way for new TB drug (post)
Drug-resistant tuberculosis is a major health challenge across much of Africa, but a new medicine being pioneered in South Africa could be a breakthrough after decades of frustration.
Tuberculosis and vitamin D: what's the rest of the story? (post)
Both protein–energy undernutrition and specific micronutrient deficiencies debilitate the cell-mediated immune system important in protection against tuberculosis.1 However, once tuberculosis develops, the disease itself induces a catabolic state resulting in negative nitrogen balance and micronutrient deficiencies. Generations of clinicians treating patients with tuberculosis believed that nutritional support was crucial to proper patient care. Why, then, has it been so difficult to prove through randomised controlled clinical trials that nutritional interventions improve tuberculosis treatment outcomes? Findings from systematic reviews2, 3, 4, 5, 6 have not shown any clear, consistent benefit in terms of tuberculosis-specific outcomes, although they do show improvements in nutritional status.
Locally-sourced drugs effective as internationally quality assured drugs for treating multidrug-resistant TB (post)
Locally-sourced antibiotics can be as effective as ‘internationally quality-assured’ (IQA) antibiotics for treating multidrug-resistant tuberculosis (MDR-TB) in Pakistan, and may help avoid delays in starting treatment while programmes wait for drugs to arrive from overseas, according to new research published in PLOS ONE.
MSF video: Push, pull and pool: accelerating innovation and access for new treatment regimens for TB (post)
Current modes of research and development have failed to deliver new and better TB regimens to patients; as such, MSF and others are proposing a new way to conduct TB regimen research, in the form of the 3P project. The ‘3P Project’ aims to rapidly deliver affordable, effective new regimens for TB through an open collaborative approach to conducting drug development, using novel approaches to financing and coordinating R&D.
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