Items tagged with Drug-resistant TB
Bedaquiline or delamanid for rifampin-resistant tuberculosis? (post)
A comment published in The Lancet Respiratory Medicine describes how to choose between bedaquiline and delamanid for an individual patient with rifampin-resistant TB, and notes, "tuberculosis programmes should make both bedaquiline and delamanid available. Although there are no efficacy data to guide the choice of one agent over the other, there are clinical scenarios that favour either bedaquiline or delamanid, and there are some patients who will need both."
Georgia on the frontlines of tackling drug-resistant TB — a photo story (post)
Georgia continues to struggle with tuberculosis (TB), today’s leading infectious disease killer, and its drug-resistant forms. The homeless, unemployed, migrants, prisoners, and people who excessively consume alcohol are among the most affected. But the good news is that the number of people suffering from drug-resistant TB has dropped over the past few years largely due to the arrival of new medicines. The first drugs to be developed in almost half a century — bedaquiline and delamanid — now offer the opportunity to treat multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) more quickly and effectively.
Delamanid to be introduced in India (post)
New Delhi, Oct 4 - Concerned over the rising number of multidrug-resistant tuberculosis (MDR-TB) cases in the country, the health ministry will introduce a new drug in a “controlled manner”.
Sequencing test enables precise identification of drug-resistant TB (post)
FLAGSTAFF, Ariz. and SAN FRANCISCO - Oct. 9, 2017 - Two studies led by the Translational Genomics Research Institute (TGen) and the University of California San Francisco (UCSF) document how a new advanced genetic sequencing approach can help thwart the growing worldwide threat posed by drug-resistant mutations of tuberculosis (TB).
STREAM clinical trial results provide vital insight into nine-month treatment regimen for multidrug-resistant TB (post)
Guadalajara, Mexico, 13 October 2017 - Preliminary results - released today at the 48th Union Conference on Lung Health - from Stage 1 of the STREAM randomised clinical trial show that the nine-month treatment regimen being tested achieved favourable outcomes in almost 80 percent of those treated.
The Medicines Patent Pool and Otsuka sign Memorandum of Understanding for paediatric formulations of delamanid for multidrug-resistant TB (post)
Geneva, 11 October 2017 — The Medicines Patent Pool (MPP) announced that it has signed a Memorandum of Understanding (MoU) with Otsuka to accelerate the development and manufacturing of, and access to, paediatric formulations containing delamanid for multidrug-resistant tuberculosis (MDR-TB).
The devil we know: is the use of injectable agents for the treatment of MDR-TB justified? (post)
Abstract
Philippines uses PViMS app to roll out groundbreaking TB drug (post)
The Philippines has one of the highest TB burdens in the world—and 2.6% of its more than 286,000 new cases in 2015 were of multi-drug-resistant TB (MDR-TB). This threatens the progress the country has made in addressing the deadly disease over the past few decades and its goal to make the country TB-free by 2030. Further, MDR-TB cases will likely rise steadily in the Philippines and the world over the next two decades.
New TB drugs are more effective and may be less toxic. Why are they still unavailable? (post)
The start of 2017 saw concern over a sharp increase in the rise of drug-resistant TB in South Africa. TB is killing millions each year. Last week, Médecins Sans Frontières published promising early data on the use of two new TB drugs, delamanid and bedaquiline, among patients living with drug-resistant TB in Khayelitsha, Cape Town. But availability remains the biggest concern.
48th Union World Conference: “While these drugs are new to the TB world, they’ve been around for a long time . . .” (post)
At a conference focused on “Accelerating toward elimination” attention turns again to stalled rollouts of the most promising medicines and regimens.
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