Items tagged with Pediatrics
Janssen announces FDA accelerated approval for SIRTURO® as part of combination therapy to treat adolescents with pulmonary MDR-TB (post)
TITUSVILLE, NJ, August 9, 2019 — The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for SIRTURO® (bedaquiline) tablets as part of combination therapy in pediatric patients – those over the age of 12 and younger than 18 and weighing at least 66 pounds (30 kilograms) – with pulmonary multidrug-resistant tuberculosis (MDR-TB), when an effective treatment regimen cannot otherwise be provided. Approved under the FDA’s accelerated approval pathway based on time to sputum culture conversion, bedaquiline can now be used as part of combination therapy for eligible MDR-TB patients aged 12 years and over in the U.S. Continued approval for this indication may be contingent upon verification of clinical benefit in confirmatory trials.
TB meningitis kills and damages nerve cells in brain through ‘overstimulation’ (post)
Study reveals how tuberculous meningitis (TBM) damages the nervous system along similar lines as chronic brain conditions such as Alzheimer’s.
Lancet Series: Tuberculosis 2019 (post)
Executive summary
Treatment-decision score for children with HIV and suspected TB (post)
A new treatment-decision score for the diagnosis of tuberculosis (TB) in children with HIV performed well, and when used in an algorithm may facilitate prompt treatment decision making for children at a high risk for mortality, according to data published in Pediatrics.
Xpert Ultra assay identifies pediatric TB with high sensitivity (post)
An updated version of the Xpert Mycobacterium tuberculosis and rifampin assay, known as Ultra, demonstrated high sensitivity in diagnosing pulmonary tuberculosis in children compared with traditional bacteriologic testing, according to research published in Pediatrics.
World Children’s Day: Message from Dr Tereza Kasaeva (post)
Dr Tereza Kasaeva, Director of the World Health Organization Global TB Program, released a message on World Children’s Day (November 20) emphasizing the need of scaling up countries' efforts to end TB in children and adolescents, and reaching the committed targets at the UN High-Level Meeting on TB.
WHO releases new guidance on treating drug-resistant TB in children and adolescents (post)
WHO/Europe has released an expert opinion on managing drug-resistant tuberculosis (DR-TB) in children and adolescents, supported by a commentary in the Lancet.
The Stop TB Partnership's Global Drug Facility Pediatric Drug-Resistant TB initiative (post)
The Stop TB Partnership’s Global Drug Facility officially launched the Pediatric Drug-Resistant TB (DR-TB) Initiative aimed at ending the disease by increasing the access of child-friendly DR-TB treatments to children who need them, wherever they are in the world.
Stop TB Partnership’s Global Drug Facility Pediatric DR-TB Initiative short film (post)
The Stop TB Partnership’s Global Drug Facility (GDF) announced the submission of a short film about the Pediatric Drug-Resistant TB (DR-TB) Initiative into the Webby Awards.
Study shows kids exposed to TB at higher risk of disease than thought (post)
Stanford scientists led the first comprehensive effort since the 1940s to measure how likely children are to develop tuberculosis when a family member has the disease.
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