Items tagged with Scientific research
Breath test for tuberculosis under development at CSU with Gates Foundation funding (post)
FORT COLLINS - Tuberculosis researchers at Colorado State University have landed a grant from the Bill and Melinda Gates Foundation to develop a diagnostic breath test with potential to revolutionize TB testing and to better control the globally devastating infectious disease.
Europe extends clinical trial project with African researchers (post)
An African-European partnership on research into some of the most serious diseases affecting the developing world has been renewed with a budget of €683m from the EU.
Students to universities: “We have a drug problem” (post)
BASEL — Students from around the world are gathering momentum to challenge their universities’ licensing policies and research and development systems. That was one of the messages emerging from the annual meeting of Universities Allied for Essential Medicines (UAEM) Europe.
TB lung infection causes changes in the diversity of gut bacteria in mice (post)
Fast Facts:
BioVersys to develop preclinical candidates in tuberculosis with the support of the University of Lille and GlaxoSmithKline (post)
BioVersys announced a collaboration with GlaxoSmithKline to develop a preclinical candidate against tuberculosis, funded by the Wellcome Trust. The collaboration will utilize BioVersys’ award-winning innovative TRIC technology that enables the discovery of Transcriptional Regulator Inhibitory Compounds. The project, built upon a very long history of TB research in Lille, will advance molecules that reactivate the efficacy of established TB therapies.
New molecular basis of attenuation and immunogenicity of the tuberculosis vaccine candidate MTBVAC described (post)
The tuberculosis vaccine candidate MTBVAC is the only vaccine in clinical trials based on an attenuated Mycobacterium tuberculosis strain of human origin. In various animal models, MTBVAC confers a similar attenuation and greater immunity than the current BCG vaccine against tuberculosis. BCG is a Mycobacterium bovis derivative, isolated from cows in the early twentieth century, which does not protect against respiratory forms of tuberculosis. MTBVAC is developed by TBVI’s research partner University of Zaragoza in collaboration with biopharmaceutical company Biofabri.
Promising protein discovered for new drugs against tuberculosis (post)
Immune cells keep tuberculosis bacteria under control by breaking them down. Leiden biologist Annemarie Meijer and her colleagues discovered which protein triggers this process. This protein (DRAM1) is a potential target for new drugs, they write in Cell Host & Microbe.
TB dogma upended: Even uninfected cells trigger immune defenses (post)
Experimenting with mice, infectious disease experts at NYU Langone Medical Center have found that immune system cells uninfected with the bacterium that causes tuberculosis trigger immune system T cells to fight the disease. The findings upend the long-held scientific belief that only cells, known specifically as dendritic cells, infected with Mycobacterium tuberculosis could stimulate a broader, defensive immune system attack of the invading microorganism.
Research may yield new ways to treat antibiotic-resistant TB (post)
CORVALLIS, Ore. – Scientists in the United States and India have successfully modified the precursor to one of the drugs used to treat tuberculosis, an important first step toward new drugs that can transcend antibiotic resistance issues that experts consider a serious threat to global health.
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