Items tagged with Scientific research
Enzyme enables tuberculosis to resist treatment (post)
Scientists have long worked to understand why antibiotics that shut down most infections offer only limited success with tuberculosis (TB), the leading bacterial cause of death around the world.
Host genetics can contribute to lung damage in severe tuberculosis (post)
A third of the global population is infected with the bacterial pathogen, a mycobacterium, that causes tuberculosis (TB). Most carriers control the infection and are asymptomatic, but severe forms of the disease (more common in children and immune-compromised adults, and often caused by particularly aggressive—or hypervirulent—mycobacterial strains) kill over a million people every year. An article published on July 3rd in PLOS Pathogens now identifies a factor made by the host that exacerbates lung damage in severe TB. The results also suggest why gene mutations that render the factor inactive are common.
Low-cost TB test means quicker, more reliable diagnosis for patients (post)
A new test for tuberculosis (TB) could dramatically improve the speed and accuracy of diagnosis for one of the world’s deadliest diseases, enabling health care providers to report results to patients within minutes, according to a study published this week in the journal Angewandte Chemie.
A quest to discover new tuberculosis drugs (post)
With a $1.5 million grant from the Bill & Melinda Gates Foundation, Cornell faculty have embarked on a quest to discover new drugs to combat tuberculosis (TB), the leading cause of death from bacterial infection. Because TB is an orphan disease –chiefly afflicting people in developing countries and offering poor profit prospects to most drug developers – this project is one of few to offer hope against an epidemic that grows more untreatable by the day.
Mycobacteria metabolism discovery may pave way for new TB drugs (post)
The mystery of why mycobacteria—a family that includes the microbe that causes TB—are extraordinarily hardy organisms is being unravelled by latest University of Otago research that offers new hope for developing a revolutionary class of antibiotics to tackle TB.
One route to malaria drug resistance found (post)
Researchers have uncovered a way the malaria parasite becomes resistant to an investigational drug. The discovery, at Washington University School of Medicine in St. Louis, also is relevant for other infectious diseases including bacterial infections and tuberculosis.
Scissoring the lipids (post)
A new strategy which enables molecules to be disconnected essentially anywhere, even remote from functionality, is described by researchers from the University of Bristol in Nature Chemistry. The method is now being developed to explore the possibility of creating a tuberculosis (TB) vaccine.
Tuberculosis transmission: Why the strains of Mycobacterium bovis are not transmitted between humans as Mycobacterium tuberculosis does? (post)
In the beginning of the XXI century, tuberculosis still causes three deaths every minute and 8 million people become infected each year. A possible explanation for the successful transmission of this disease relies on the aerial propagation from infected patients. Tuberculosis also affects a variety of mammals including cattle, but disease in humans and animals is caused by different species of the Mycobacterium genus: Mycobacterium tuberculosis and Mycobacterium bovis respectively. However, it is worthy to remember that bacteria responsible for tuberculosis in cattle are rarely transmitted to and between humans.
New study to improve tuberculosis treatments (post)
The University of Southampton has been awarded $1.4 million (approximately £833,260) to develop new treatments to fight tuberculosis.
Researchers uncover clues about how the most important TB drug attacks its target (post)
Findings could help researchers discover better medications for TB and other persistent bacterial infections
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