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Items tagged with Scientific research

Researchers develop methods to understand how tuberculosis bacillus consumes some of its favourite foods (post)

Tuberculosis is a deadly yet curable infectious disease caused by a bacterium called Mycobacterium tuberculosis which remains the second leading cause of infectious death globally. According to the World Health Organization, a total of 1.4 million people died from tuberculosis in 2019.

Innovative collaboration leads to new insights into TB immune response (post)

New research using human lung samples and three-dimensional bioengineering techniques to replicate the lung environment has revealed the important role of a subset of immune cells in the lung in fighting tuberculosis (TB). The cells, called T Helper 17 cells, or Th17, have been found to be important in animal models of TB, but are rarely detected in the blood of humans and so their importance in human disease has not been clear until now.

Who gets sick with TB? Deficient immune cells implicated in TB disease progression (post)

Nearly a quarter of the world’s population is estimated to be infected with Mycobacterium tuberculosis (M.tb), the pathogen that causes tuberculosis, but less than 15 percent of infected individuals develop the disease.

New studies identify how TB destroy the lungs and how to protect them (post)

Two new studies have cast unprecedented light on disease processes in tuberculosis, identifying key genetic changes that cause damage in the lungs and a drug treatment that could speed up recovery.

Scientists solve one of TB’s deadliest tricks (post)

Tuberculosis (TB) isn’t very common in the US, but worldwide it causes an immense amount of suffering.

Stem cells may hold a key to developing new vaccines against COVID-19 (post)

Coronavirus activates a stem cell-mediated defense mechanism that reactivates dormant TB in a mouse model and has implications for developing new vaccines and avoiding a global TB pandemic, report investigators in The American Journal of Pathology.

Praedicare Inc. receives grant to evaluate potential new drug regimens for TB (post)

DALLAS, June 17, 2021 -- Praedicare Inc., a CRO using unique pre-clinical laboratory and proprietary mathematical translation models today announced it has been awarded a two-year, $2.8 million grant by the Bill & Melinda Gates Foundation to evaluate novel TB drug regimens using Praedicare’s in vitro hollow fiber model of tuberculosis (TB) in identifying potential new drug regimens that shorten treatment times for the disease.

Hackensack Meridian CDI scientists discover new tuberculosis treatment pathway (post)

Scientists from the Hackensack Meridian Center for Discovery and Innovation, working with collaborators from across the globe, uncovered the mechanism of action of a novel anti-tuberculosis drug that they have helped develop.

Structural biology reveals new opportunities to combat tuberculosis (post)

EMBL Hamburg’s Wilmanns and Kosinski groups have determined the detailed structure of a bacterial protein complex critical for tuberculosis infection.

Progress towards new treatments for tuberculosis (post)

Boosting the body’s own disease-fighting immune pathway could provide answers in the desperate search for new treatments for tuberculosis.

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