Items tagged with Scientific research
Hepatitis drug increases antibiotic potency, limits antibiotic resistance (post)
Cellular study of telaprevir shows that the antiviral blocks the function of essential proteins in bacteria, revealing opportunity to repurpose drug to use alongside antibiotics.
Evidence and research gaps identified during development of policy guidelines for TB (post)
Achieving the goals and targets of the World Health Organization (WHO) End TB Strategy requires innovative tools and strategies as well as rapid progress towards universal access.
Researchers first to predict when bacteria may become resistant to antibiotics (post)
Scientists have spotted signs of ‘pre-resistance’ in bacteria for the first time – signs that particular bacteria are likely to become resistant to antibiotics in the future – in a new study led by UCL and Great Ormond Street Hospital researchers.
Computational models move researchers closer to TB vaccine (post)
According to a 2021 World Health Organization report, the global COVID-19 pandemic caused an increase in tuberculosis (TB) deaths – 1.5 million in 2020 versus 1.4 million in 2019 – due to a lack of efficient diagnosis and treatment. Since TB has been the number one cause of death from infectious disease in the world for centuries, University of Michigan (UM) Medical School Professor Denise Kirschner and colleagues have been working to better understand the disease by using supercomputers like Expanse at the San Diego Supercomputer Center at UC San Diego.
With TB resurgent after two years of COVID-19-inspired neglect, TB Alliance is awarded USAID funding to develop new treatments (post)
NEW YORK, NY (20 January 2022) — Today, TB Alliance announced that it has received funding from the United States Agency for International Development (USAID) to jumpstart the search for new tuberculosis (TB) treatments, optimize current treatments so that they can treat children as well as adults, and strengthen health systems in high-TB-burden countries so that all people with TB disease can get treated and quickly return to full health. The funding of up to US$30 million will be administered over a period of 5 years.
New vaccine may provide better treatment for TB (post)
A new vaccine against tuberculosis may also be used as treatment. The vaccine is safe to give to people with tuberculosis disease and strengthens the immune system's ability to attack the bacteria that cause the disease, a new study shows.
Possible new method identified to assess severity of TB infection (post)
Researchers at Washington University School of Medicine in St. Louis have discovered a molecule in the lungs of tuberculosis (TB) patients that reflects the levels of TB-causing bacteria in the lungs, information needed to better address the notoriously difficult to treat disease.
Epigenetic-mediated immune mechanisms identified in TB (post)
A histone acetylome-wide associations study (HAWAS) performed in immune cells from patients with active Mycobacterium tuberculosis infection versus those from healthy controls, has for the first time provided proof of principle for HAWAS to infer molecular mechanisms of host response to pathogens.
Starting antiretroviral therapy early essential to battling not one, but two killers (post)
SAN ANTONIO (February 15, 2022) – Two weeks makes a big difference in treating the animal version of HIV and latent tuberculosis, researchers from Texas Biomedical Research Institute, Southwest National Primate Research Center and colleagues report this month in the Journal of Clinical Investigation. The finding is another piece in the puzzle of the complex interaction between HIV and tuberculosis (TB), and can help advance development of therapies and a combined vaccine for the two diseases in humans.
Analysis of DNA reveals weapons used by our immune cells to fight TB (post)
A study led by the Agency for Science, Technology and Research's (A*STAR) Genome Institute of Singapore (GIS) and Infectious Diseases Labs (ID Labs) has identified a gene, KCNJ15, that is associated with helping our immune system fight tuberculosis (TB), and potentially other infectious diseases. The research was published in Nature Microbiology on 31 January 2022.
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