Items tagged with Scientific research
TB researchers find link between vaccine efficacy, environmental pathogens (post)
Tuberculosis is an infectious disease of the lungs that’s been with humanity for centuries and affects a quarter of the world’s population. The stubborn disease killed over a million and a half people in 2021, mostly in lower- and middle- income countries where access to basic resources is scarce.
New study into TB membrane molecules will aid drug delivery (post)
TB rivals Covid-19 as the biggest infectious disease killer of humans, claiming millions of lives each year. Now, ground-breaking research from the Universities of Warwick and Toulouse has identified a new method to help tackle this global issue.
Drugs affect individual cells differently, finds new Surrey research (post)
A new state-of-the-art method that measures the amounts of drugs and lipids (fats) in individual cells could help health professionals target more effective treatments for diseases such as TB.
Genomic study reveals signs of TB adaptation in ancient Andeans (post)
People have inhabited the Andes mountains of South America for more than 9,000 years, adapting to the scarce oxygen available at high altitudes, along with cold temperatures and intense ultraviolet radiation. A new genomic study suggests that Indigenous populations in present-day Ecuador also adapted to the tuberculosis bacterium, thousands of years before the arrival of Europeans.
Signaling proteins shown to play key role in TB biology (post)
A set of 10 signaling proteins found in the microbe that causes tuberculosis [TB], play a far larger role in regulating the bacterium’s growth, development and behavior than previously thought, according to recent research. The study was led by University of Washington School of Medicine and Seattle Children's researchers..
NIH grant supports TB research network in Brazil (post)
The National Institutes of Health (NIH) has awarded a five-year, $5 million grant to Vanderbilt University Medical Center for continued support of the Brazil Regional Prospective Observational Research in Tuberculosis network, or RePORT-Brazil.
Temperature-stable TB vaccine safe, prompts immune response in NIH-supported study (post)
A clinical trial testing a freeze-dried, temperature-stable experimental tuberculosis (TB) vaccine in healthy adults found that it was safe and stimulated both antibodies and responses from the cellular arm of the immune system. The Phase 1 trial was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. A non-temperature stable form of the candidate previously had been tested in several clinical trials. However, this was the first clinical trial of any subunit TB vaccine candidate in a temperature-stable (thermostable) form. Results are published in Nature Communications.
Frozen cells reveal a clue for a vaccine to block the deadly TB bug (post)
Tuberculosis may seem like a relic of the past in wealthy countries, yet it still kills more people worldwide than any other infectious disease besides COVID – with about 1.6 million people dying from TB annually. And the one approved vaccine – invented more than a century ago – is only reliably protective when given to children.
Cornell-developed anti-TB compound headed to trials (post)
A novel compound that has the potential to starve the bacteria that causes tuberculosis – the world’s leading infectious killer after SARS-CoV2 – is entering human clinical trials.
Wayne State researchers develop new technology to easily detect active TB (post)
DETROIT, March 13, 2023 – A team of faculty from Wayne State University has discovered new technology that will quickly and easily detect active Mycobacterium tuberculosis (TB) infection antibodies. Their work, “Discovery of Novel Transketolase Epitopes and the Development of IgG-Based Tuberculosis Serodiagnostics,” was published in a recent edition of Microbiology Spectrum, a journal published by the American Society for Microbiology. The team is led by Lobelia Samavati, M.D., professor in the Center for Molecular Medicine and Genetics in the School of Medicine. Samavati was joined by Jaya Talreja, Ph.D, and Changya Peng, research scientists in Wayne State’s Department of Internal Medicine.
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