Items tagged with Scientific research
Treating TB when antibiotics no longer work (post)
A research team has detected various substances that have a dual effect against tuberculosis: They make the bacteria causing the disease less pathogenic for human immune cells and boost the activity of conventional antibiotics.
Remodeling the immune system to fight TB (post)
Collaborative team from UMass Amherst and Seattle Children’s Research Institute uncovers how prior exposure to bacteria changes the lung’s innate immune response – and what it might mean for vaccines.
Welch Foundation grant supports research on drug-resistant TB (post)
With a $300,000 grant, the Welch Foundation is supporting University of Texas at Arlington (UTA) research into why some types of Mycobacterium tuberculosis (Mtb), the bacteria that causes the lung disease tuberculosis (TB), do not respond to treatments.
LifeArc makes multi-million pound investment to support drug discovery in sub-Saharan Africa (post)
LifeArc and the Bill & Melinda Gates Foundation are jointly investing £6 million ($7.2m) in the Grand Challenges African Drug Discovery Accelerator (GC ADDA) programme, a collaboration that will support 5 African drug discovery projects over 3 to 5 years.
How T cells combat TB (post)
LA JOLLA, CA, February 6, 2024 — La Jolla Institute for Immunology (LJI) is working to guide the development of new tuberculosis vaccines and drug therapies.
Study reveals mechanism that aggravates TB and reduces survival rates (post)
CD4+ T cells have been highlighted in the scientific literature for the important role they play in the immune response to lung infections. However, an article published in the journal Cell Reports shows that an imbalance in the volumes of these defense cells in different parts of the lung in response to infection can do more harm than good.
Upending the dogma of TB latency: Will it offer new clues for vaccine research? (post)
There are many reasons why HIV is such a perplexing virus to combat. One of them is that there are incredibly few people — only a few, if that, of the nearly 86 million people to acquire HIV to date — who have naturally cleared the virus after becoming infected. Once an HIV infection occurs, it almost always persists in the body for a lifetime.
TB bacteria also present in those who are not diagnosed with TB (post)
March 12, 2024 -- Mycobacterium tuberculosis (Mtb), the bacteria that causes a tuberculosis infection, is present in exhaled breath of 90% of those presenting with suspected tuberculosis. This includes those who were negative on conventional sputum testing and not diagnosed with TB. This raises the possibility that those who have tested negative may be unknowingly transmitting the infection. Researchers from the University of Cape Town and Amsterdam UMC analysed results from over 100 patients who presented themselves to clinics in South Africa. These findings are published today in PNAS.
No persistent cough in four out of five with TB (post)
March 13, 2024 -- More than 80% of patients with tuberculosis, the world’s most deadly infection, do not have a persistent cough, despite this being seen as a key symptom of the disease. The infection is predominantly transmitted by coughing, but probably also through simply breathing. Research, led by Amsterdam UMC and the Amsterdam Institute for Global Heath and Development, analysed data on more than 600,000 individuals in Africa and Asia and found that 82.8% of those with tuberculosis had no persistent cough and 62.5% had no cough at all. These results are published today in the Lancet Infectious Diseases.
New research shows promise for novel treatments for TB (post)
Collaborative research from Trinity and RCSI University of Medicine and Health Sciences is recently published in the European Journal of Pharmaceutical Sciences and marked World TB Day (24th March 2024).
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