Items tagged with Scientific research
Mouse studies show experimental TB treatment may do more harm than good (post)
Johns Hopkins researchers report evidence from mouse studies that a “repurposed” drug that would be expected to improve the immune system response of tuberculosis patients may be increasing resistance to the antibiotic drugs these patients must also take.
No consensus on how the microbiome affects tuberculosis, review finds (post)
Inconsistencies across studies and sampling errors remain major barriers to understanding how the lung microbiome changes with tuberculosis, according to a review published Wednesday in Clinical Microbiology Reviews.
Scientists identify new target for TB drug development (post)
Scientists led by Dr Luiz Pedro Carvalho at the Francis Crick Institute in London have found a promising new target in the search for new tuberculosis drugs. In the process, they say they've proven the strengths of a new research technique called metabolomics.
Antibody function may help keep TB under control (post)
A study led by investigators from the Ragon Institute of MGH, MIT and Harvard finds evidence that antibody protection may help control infection with the bacteria that causes tuberculosis (TB). In their study receiving online publication in Cell, the research team describes finding consistent differences in both the structure and function of antibodies targeting the TB bacteria between individuals with active TB disease and those with latent TB, which neither produces symptoms nor can be transmitted. The findings may lead to better ways of distinguishing between active and latent disease and to a more effective vaccine against a disease that kills more than 1.5 million people each year.
Aeras launches AerasSHARE Biorepository to help advance TB vaccine research (post)
Rockville, MD, September 28, 2016 –Aeras, a nonprofit research and development organization dedicated to the development of new TB vaccines, has launched the AerasSHARE Biorepository, a new website to allow researchers from other organizations to access specimens and datasets that were collected by Aeras and its research partners in an effort to facilitate state-of-the-art TB vaccine related science and promote world-wide collaboration among TB vaccine researchers.
Antibiotics developed in 1960s show promise for TB therapy (post)
First generation cephalosporins—antibiotics introduced as a treatment against bacterial infections in 1963—now show promise for tuberculosis (TB) therapy, according to new research published in Scientific Reports.
Mystery of bacteria's antibiotic resistance unravelled (post)
A popular antibiotic called rifampicin, used to treat tuberculosis, leprosy, and Legionnaire's disease, is becoming less effective as the bacteria that cause the diseases develop more resistance.
Status of vaccine research and development of TB vaccines (post)
Abstract
TB tricks the body’s immune system to allow it to spread (post)
Tuberculosis (TB) tricks the immune system into attacking the body’s lung tissue so the bacteria are allowed to spread to other people, new research from the University of Southampton suggests.
TB-ReFLECT: A collaborative effort to enhance TB clinical research (post)
TUCSON, Ariz., October 25, 2016 - The Critical Path Institute's Critical Path to TB Drug Regimens (CPTR) initiative and the Global TB Programme of the World Health Organization (WHO) have partnered with researchers from the University of California, San Francisco (UCSF), to develop leading-edge quantitative analyses of data from the TB-Platform for Aggregation of Clinical TB Studies (TB-PACTS) database. This collaboration, called TB-ReFLECT, will extract from these analyses key lessons from the TB-PACTS platform, and then package such lessons as tools for future TB trial design.
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